Role of acid‐base and hydration‐dehydration equilibria on reductions of chloral and chloral hydrate

Chloral and Chloral Hydrate

These substances were considered by a previous Working Group, in February 1995 (IARC, 1995). Since that time, new data have become available and these have been incorporated into the monograph and taken into consideration in the present evaluation.

Chloral and Chloral Hydrate

Chloral hydrate

Major uses Chloral hydrate (synthesized in 1832 and introduced into medicine 1869) is the oldest member of sedative-hypnotic drugs. To the same group belong paraldehyde, bromide, urethane, and sulfonal. Metabolite of chloral hydrate, trichloroethanol, is also an excellent hypnotic agent, but is not often used as such due to its physical and irritant properties. At present, chloral hydrate is la...

Chloral hydrate warning.

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Hydrate of Chloral in Tetanus

"With reference to treatment, it will be noticed that ot the 83 cases, two absconded from the hospital, so that, practically, we have to deal with 81 instances of tetanus, and of these 13 are stated as having been " relieved" when discharged from hospital; this is doubtless a very unsatisfactory way of accounting for cases of tetanus, but it is unavoidable in this country ; the friends of the p...